Cymbalta (duloxetine) is used to treat the major symptoms of depression and generalized anxiety disorder, but there are also a range of other conditions for which it could be prescribed. This drug works by increasing the amounts of two natural substances in the brain (serotonin and norepinephrine) and stopping the pain signals sent by the brain. Although this side effect is rare, in some cases people taking Cymbalta can have suicidal thoughts and plans. To prevent you from developing these symptoms, in case you are younger than 24, your health care provider will want you to show up for regular appointments to make sure you are benefitting from the treatment. You must swallow the extended-release capsule whole, without breaking it or chewing on it. This is necessary to make sure the medicine is dissolved in your stomach, and not in the esophagus, to provide for maximum effects.